Situated right outside the city centre, the Opera Rooms 66 is within a 10 minute walk to Rione Monti, National Museum of Rome and Basilica di Santa Maria Maggiore. The neighbourhood is well-known for shopping. Rome's attractions, such as Basilica of St. Mary of the Angels and the Martyrs, Church of Our Lady of Victory and Church of Saint Susanna at the Baths of Diocletian are easily accessible on foot.

This bed and breakfast is in Rome's Vatican City district, a short stroll to Church of Saint Charles at the Four Fountains. Wi-Fi access is available. Non-smoking rooms are available on request.